A-138 Investigation of Potential Involvement of The Adrenal Cortex In The Pathogenesis of Autism In Prepubertal Male Jordanian Children
نویسندگان
چکیده
Abstract Objective: The investigation of adrenal steroids and testosterone levels in male autistic children will, undoubtedly, help to elucidate the pathogenetic implication these hormones development autism their role as risk factors. objective this case-control study is explore potential involvement pathogenesis autism. Method: Serum total (TT), dehydroepiandrosterone (DHEA) sex-hormone binding globulin (SHBG) were measured 32 Jordanian patients healthy age-matched children. Independent t-test was used investigate statistical significance groups with a (p) value less than 0.05 considered significant. Preliminary univariate logistic regression assess which lab parameters should be included final models. Multivariable (backward stepwise selection) prediction. Results: TT had positive strong correlation DHEA (r=+62, p≤0.001), suggesting an source elevated androgens. Likelihood developing increased by 1.03 times for increase one ng/dl DHEA, 0.92 nmol/l SHBG only 0.04 mIU/ml FSH. Conclusions: demonstrated between pre-pubertal further substantiates cortex Further studies are needed prediction
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ژورنال
عنوان ژورنال: Archives of Clinical Neuropsychology
سال: 2022
ISSN: ['1873-5843', '0887-6177']
DOI: https://doi.org/10.1093/arclin/acac060.138